Pelizaeus-Merzbacher disease: pathogenic mechanisms and insights into the roles of proteolipid protein 1 in the nervous system

J Neurol Sci. 2005 Feb 15;228(2):201-3. doi: 10.1016/j.jns.2004.10.010. Epub 2004 Dec 16.

Author

James Y Garbern¹

Affiliation

¹ Department of Neurology and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 421 E. Canfield, Elliman Building, Room 3217, Detroit, MI 48201, USA. jgarbern@med.wayne.edu

PMID: 15694206
DOI: 10.1016/j.jns.2004.10.010

No abstract available

Publication types

Review

MeSH terms

Animals
Central Nervous System / metabolism
Central Nervous System / pathology
Central Nervous System / physiopathology*
Disease Models, Animal
Humans
Mutation / genetics
Myelin Proteolipid Protein / chemistry
Myelin Proteolipid Protein / genetics*
Myelin Proteolipid Protein / metabolism
Myelin Sheath / genetics*
Myelin Sheath / metabolism*
Myelin Sheath / pathology
Nerve Fibers, Myelinated / metabolism*
Nerve Fibers, Myelinated / pathology
Neuroglia / metabolism
Pelizaeus-Merzbacher Disease / genetics*
Pelizaeus-Merzbacher Disease / metabolism
Pelizaeus-Merzbacher Disease / physiopathology
Wallerian Degeneration / genetics
Wallerian Degeneration / metabolism
Wallerian Degeneration / physiopathology

Substances

Myelin Proteolipid Protein