The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway

Brain Res. 2005 May 17;1044(1):127-31. doi: 10.1016/j.brainres.2005.03.011. Epub 2005 Apr 7.

Abstract

The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract and the brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require an intact vagal-brainstem-hypothalamic pathway to affect CNS feeding circuits. We have shown that the effects of peripheral administration of both peptide YY(3-36) (PYY(3-36)) and glucagon-like peptide-1 (GLP-1) on food intake and activation of hypothalamic arcuate feeding neurones are abolished following either bilateral sub-diaphragmatic total truncal vagotomy or brainstem-hypothalamic pathway transectioning in rodents. These findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY(3-36) and GLP-1 on food intake.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain Stem / drug effects*
  • Brain Stem / physiology
  • Denervation / methods
  • Eating / drug effects*
  • Efferent Pathways / drug effects
  • Efferent Pathways / physiology
  • Hypothalamus / drug effects*
  • Hypothalamus / physiology
  • Inhibition, Psychological
  • Intercellular Signaling Peptides and Proteins
  • Male
  • Naphthalenes
  • Oxepins
  • Peptide Fragments
  • Peptide YY / administration & dosage*
  • Peptides / administration & dosage*
  • Rats
  • Rats, Wistar
  • Vagotomy / methods
  • Vagus Nerve / drug effects*
  • Vagus Nerve / physiology

Substances

  • 1-phenyl-1,4-epoxy-1H,4H-naphtho(1,8-de)(1,2)dioxepin
  • Intercellular Signaling Peptides and Proteins
  • Naphthalenes
  • Oxepins
  • Peptide Fragments
  • Peptides
  • Peptide YY
  • peptide YY (3-36)
  • glucagon releasing peptide