No rest for REST: REST/NRSF regulation of neurogenesis

Victoria V Lunyak; Michael G Rosenfeld

doi:10.1016/j.cell.2005.05.003

No rest for REST: REST/NRSF regulation of neurogenesis

Cell. 2005 May 20;121(4):499-501. doi: 10.1016/j.cell.2005.05.003.

Authors

Victoria V Lunyak¹, Michael G Rosenfeld²

Affiliations

¹ Department of Medicine, University of California, San Diego, Howard Hughes Medical Institute, La Jolla, California.
² Department of Medicine, University of California, San Diego, Howard Hughes Medical Institute, La Jolla, California. Electronic address: mrosenfeld@ucsd.edu.

PMID: 15907461
DOI: 10.1016/j.cell.2005.05.003

Abstract

Epigenetic strategies control the orderly acquisition and maintenance of neuronal traits. A complex network of transcriptional repressors and co-repressors mediates gene specificity for these strategies. In this issue of Cell, a study by Ballas and coworkers (Ballas et al., 2005) provides insight into the early lineage commitment events during neurogenesis. This study demonstrates that regulation of the REST/NRSF transcriptional repressor plays a fundamental role in the progression of pluripotent cells to lineage-restricted neural progenitors.

Publication types

Comment
Review

MeSH terms

Animals
Cell Differentiation / physiology*
Cell Lineage / physiology
Epigenesis, Genetic / physiology
Gene Expression Regulation, Developmental / physiology
Humans
Nervous System / cytology
Nervous System / embryology
Nervous System / metabolism*
Neurons / cytology
Neurons / metabolism*
Pluripotent Stem Cells / cytology
Pluripotent Stem Cells / metabolism*
Repressor Proteins / genetics
Repressor Proteins / metabolism*
Transcription Factors / genetics
Transcription Factors / metabolism*

Substances

RE1-silencing transcription factor
Repressor Proteins
Transcription Factors