Stem cell grand SLAM

Cell. 2005 Jul 1;121(7):967-70. doi: 10.1016/j.cell.2005.06.017.

Abstract

Stem cells in both embryonic and adult tissues are defined by their unique ability to balance self-renewal and differentiation such that mature cells necessary for tissue function can be generated and replaced without depletion of the stem cell pool. In this issue of Cell, report a major step forward for studying the mechanisms and regulation of such stem cell fate decisions in the blood-forming (hematopoietic) system by providing a simple and broadly applicable method to isolate these cells and to visualize them in their normal environment.

Publication types

  • Review
  • Comment

MeSH terms

  • Animals
  • Antigens, CD
  • Biomarkers / metabolism
  • Cell Differentiation / immunology*
  • Cell Lineage / immunology*
  • Cell Proliferation
  • Cell Separation / methods
  • Endothelial Cells / immunology
  • Glycoproteins / immunology*
  • Hematopoiesis / immunology*
  • Hematopoietic Stem Cells / immunology*
  • Humans
  • Immunoglobulins / immunology*
  • Receptors, Cell Surface
  • Signaling Lymphocytic Activation Molecule Family Member 1

Substances

  • Antigens, CD
  • Biomarkers
  • Glycoproteins
  • Immunoglobulins
  • Receptors, Cell Surface
  • Signaling Lymphocytic Activation Molecule Family Member 1