The actin cytoskeleton: a key regulator of apoptosis and ageing?

Campbell W Gourlay; Kathryn R Ayscough

doi:10.1038/nrm1682

The actin cytoskeleton: a key regulator of apoptosis and ageing?

Nat Rev Mol Cell Biol. 2005 Jul;6(7):583-9. doi: 10.1038/nrm1682.

Authors

Campbell W Gourlay¹, Kathryn R Ayscough

Affiliation

¹ Department of Molecular Biology and Biotechnology, Firth Court, Western Bank, University of Sheffield, Sheffield, S10 2TN, UK.

PMID: 16072039
DOI: 10.1038/nrm1682

Abstract

Evidence from many organisms has shown that the accumulation of reactive oxygen species (ROS) has a detrimental effect on cell well-being. High levels of ROS have been linked to programmed cell death pathways and to ageing. Recent reports have implicated changes to the dynamics of the actin cytoskeleton in the release of ROS from mitochondria and subsequent cell death.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Actins / physiology*
Aging / physiology*
Animals
Apoptosis / physiology*
Cell Death
Cytoskeleton / physiology*
Humans
Oxygen Consumption
Reactive Oxygen Species / metabolism
Saccharomyces cerevisiae / growth & development
Signal Transduction / physiology*

Substances

Actins
Reactive Oxygen Species