DNA methyltransferases and structural-functional specificity of eukaryotic DNA modification

Ya I Buryanov; T V Shevchuk

doi:10.1007/s10541-005-0178-0

DNA methyltransferases and structural-functional specificity of eukaryotic DNA modification

Biochemistry (Mosc). 2005 Jul;70(7):730-42. doi: 10.1007/s10541-005-0178-0.

Authors

Ya I Buryanov¹, T V Shevchuk

Affiliation

¹ Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. buryanov@fibkh.serpukhov.su

PMID: 16097936
DOI: 10.1007/s10541-005-0178-0

Abstract

Properties of the main families of mammalian, plant, and fungal DNA methyltransferases are considered. Structural-functional specificity of eukaryotic genome sequences methylated by DNA methyltransferases is characterized. The total methylation of cytosine in DNA sequences is described, as well as its relation with RNA interference. Mechanisms of regulation of expression and modulation of DNA methyltransferase activity in the eukaryotic cell are discussed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
DNA / chemistry*
DNA / genetics
DNA / metabolism*
DNA Modification Methylases / chemistry*
DNA Modification Methylases / genetics
DNA Modification Methylases / metabolism*
Eukaryotic Cells / metabolism*
Gene Expression Regulation, Enzymologic
Humans
Sensitivity and Specificity
Sequence Analysis, DNA

Substances

DNA
DNA Modification Methylases