Abstract
Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Animals
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Disease Models, Animal
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Gene Deletion
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Homeodomain Proteins / genetics*
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Homeodomain Proteins / metabolism
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Insulin / blood
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Leptin / blood
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Lipid Metabolism / genetics*
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Lipids / analysis
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Liver / metabolism
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Lymph / metabolism
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Lymphatic Abnormalities / complications
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Lymphatic Abnormalities / genetics*
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Lymphatic Vessels / abnormalities
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Lymphatic Vessels / physiopathology
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Mice
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Mice, Knockout
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Obesity / complications
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Obesity / genetics*
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Tumor Suppressor Proteins
Substances
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Homeodomain Proteins
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Insulin
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Leptin
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Lipids
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Tumor Suppressor Proteins
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prospero-related homeobox 1 protein