Abstract
Some individuals maintain high cognitive functioning at older ages. Here we show that mechanisms for long-term depression differ in aged rodents that maintain cognitive performance compared to young adults. Our results imply that cognitive abilities may be sustained in aged individuals by a switch in synaptic plasticity mechanisms.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adaptation, Physiological / physiology
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Aging / physiology*
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Animals
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Cognition / drug effects
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Cognition / physiology*
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Cognition Disorders / metabolism
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Cognition Disorders / physiopathology
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Electric Stimulation
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Excitatory Amino Acid Antagonists / pharmacology
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Glutamic Acid / metabolism
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Hippocampus / physiology*
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Long-Term Synaptic Depression / physiology*
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Maze Learning / drug effects
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Maze Learning / physiology
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Memory Disorders / metabolism
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Memory Disorders / physiopathology
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Neuronal Plasticity / physiology
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Organ Culture Techniques
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Rats
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Rats, Long-Evans
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Receptors, N-Methyl-D-Aspartate / physiology*
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Species Specificity
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
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Type C Phospholipases / antagonists & inhibitors
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Type C Phospholipases / metabolism
Substances
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Excitatory Amino Acid Antagonists
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Receptors, N-Methyl-D-Aspartate
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Glutamic Acid
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Type C Phospholipases