Abstract
The binding properties of ligands specific for two subclasses of glutamate receptors were studied by quantitative autoradiography after one hour of acute immobilization/shock stress. [3H]N-(1-(2-thienyl)cyclohexyl)-3,4-piperidine (TCP) and [3H]alpha-amino-3-methylisoxazole-4-propionic acid (AMPA) were used to visualize the N-methyl-D-aspartate receptor and the AMPA/quisqualate receptor types, respectively. While no change was observed in the binding properties of the [3H]TCP, [3H]AMPA binding was significantly increased in several areas of the hippocampus of acutely stressed rats relative to naive controls.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Autoradiography
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Electroshock
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Hippocampus / anatomy & histology
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Hippocampus / metabolism*
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Ibotenic Acid / analogs & derivatives*
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Ibotenic Acid / metabolism
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Phencyclidine / analogs & derivatives
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Phencyclidine / metabolism
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Rats
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Receptors, AMPA
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Receptors, N-Methyl-D-Aspartate / drug effects
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Receptors, Neurotransmitter / metabolism*
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Restraint, Physical
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Stress, Psychological / metabolism*
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Synaptic Transmission / physiology
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Substances
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Receptors, AMPA
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Receptors, N-Methyl-D-Aspartate
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Receptors, Neurotransmitter
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Ibotenic Acid
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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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tenocyclidine
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Phencyclidine