Closing the GAP between polarity and vesicle transport

Ian G Macara; Anne Spang

doi:10.1016/j.cell.2006.04.011

Closing the GAP between polarity and vesicle transport

Cell. 2006 May 5;125(3):419-21. doi: 10.1016/j.cell.2006.04.011.

Authors

Ian G Macara¹, Anne Spang

Affiliation

¹ Center for Cell Signaling, Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA. imacara@virginia.edu

PMID: 16678084
DOI: 10.1016/j.cell.2006.04.011

Abstract

How are tight junctions maintained? In this issue of Cell, Wells et al. (2006) provide intriguing evidence for a new pathway that links polarity proteins and vesicle transport to the maintenance of tight junctions, through the control of Cdc42 by Rich1, a GTPase-activating protein.

Publication types

Comment
Review

MeSH terms

Animals
Cell Polarity / physiology*
GTPase-Activating Proteins / metabolism*
Humans
Membrane Proteins / metabolism*
Protein Transport / physiology
Signal Transduction / physiology
Tight Junctions / metabolism*
Transport Vesicles / metabolism*
cdc42 GTP-Binding Protein / metabolism

Substances

GTPase-Activating Proteins
Membrane Proteins
cdc42 GTP-Binding Protein