Abstract
We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30-44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Amygdala / physiology*
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Depression / metabolism
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Feedback / physiology
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Homeostasis / physiology*
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Humans
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Magnetic Resonance Imaging
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Oxygen / blood
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Piperazines / pharmacology
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Positron-Emission Tomography
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Pyridines / pharmacology
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Receptor, Serotonin, 5-HT1A / drug effects
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Receptor, Serotonin, 5-HT1A / physiology*
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Serotonin Antagonists / pharmacology
Substances
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Piperazines
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Pyridines
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Serotonin Antagonists
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Receptor, Serotonin, 5-HT1A
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N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
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Oxygen