A role for p130Cas in mechanotransduction

Benjamin Geiger

doi:10.1016/j.cell.2006.11.020

A role for p130Cas in mechanotransduction

Cell. 2006 Dec 1;127(5):879-81. doi: 10.1016/j.cell.2006.11.020.

Author

Benjamin Geiger¹

Affiliation

¹ Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, 76100, Israel. benny.geiger@weizmann.ac.il

PMID: 17129774
DOI: 10.1016/j.cell.2006.11.020

Abstract

Focal adhesions are sites of contact between cells and the extracellular matrix. Sawada et al. (2006) now report that the mechanical stretching of cells forces p130Cas, an adaptor protein at focal adhesions, to undergo a conformational change. This change promotes phosphorylation of p130Cas by Src family kinases and the transduction of integrin-mediated signaling.

Publication types

Comment
Research Support, N.I.H., Extramural

MeSH terms

Biomechanical Phenomena
Crk-Associated Substrate Protein / chemistry
Crk-Associated Substrate Protein / metabolism*
Focal Adhesions / metabolism
Humans
Mechanotransduction, Cellular*
Phosphotyrosine / metabolism
Substrate Specificity
src-Family Kinases / metabolism

Substances

Crk-Associated Substrate Protein
Phosphotyrosine
src-Family Kinases

Grants and funding

U54 GM64346/GM/NIGMS NIH HHS/United States