Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain

J Comp Neurol. 2007 Feb 20;500(6):1007-33. doi: 10.1002/cne.21229.

Abstract

We previously demonstrated that chemokine receptors are expressed by neural progenitors grown as cultured neurospheres. To examine the significance of these findings for neural progenitor function in vivo, we investigated whether chemokine receptors were expressed by cells having the characteristics of neural progenitors in neurogenic regions of the postnatal brain. Using in situ hybridization we demonstrated the expression of CCR1, CCR2, CCR5, CXCR3, and CXCR4 chemokine receptors by cells in the dentate gyrus (DG), subventricular zone of the lateral ventricle, and olfactory bulb. The pattern of expression for all of these receptors was similar, including regions where neural progenitors normally reside. In addition, we attempted to colocalize chemokine receptors with markers for neural progenitors. In order to do this we used nestin-EGFP and TLX-LacZ transgenic mice, as well as labeling for Ki67, a marker for dividing cells. In all three areas of the brain we demonstrated colocalization of chemokine receptors with these three markers in populations of cells. Expression of chemokine receptors by neural progenitors was further confirmed using CXCR4-EGFP BAC transgenic mice. Expression of CXCR4 in the DG included cells that expressed nestin and GFAP as well as cells that appeared to be immature granule neurons expressing PSA-NCAM, calretinin, and Prox-1. CXCR4-expressing cells in the DG were found in close proximity to immature granule neurons that expressed the chemokine SDF-1/CXCL12. Cells expressing CXCR4 frequently coexpressed CCR2 receptors. These data support the hypothesis that chemokine receptors are important in regulating the migration of progenitor cells in postnatal brain.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Movement / physiology
  • Chemotaxis
  • Dentate Gyrus / cytology
  • Dentate Gyrus / metabolism
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental / physiology
  • Immunohistochemistry
  • Lateral Ventricles / cytology
  • Lateral Ventricles / metabolism
  • Limbic System / cytology
  • Limbic System / growth & development
  • Limbic System / metabolism*
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Morphogenesis / physiology
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Neurons / cytology
  • Neurons / metabolism*
  • Olfactory Bulb / metabolism
  • Receptors, Chemokine / genetics
  • Receptors, Chemokine / metabolism*
  • Stem Cells / cytology
  • Stem Cells / metabolism*

Substances

  • Nerve Tissue Proteins
  • Receptors, Chemokine