Abstract
Mucolipin 1 (MLN1), also known as TRPML1, is a member of the mucolipin family. The mucolipins are the only lysosomal proteins within the TRP superfamily. Mutations in the gene coding for TRPML1 result in a lysosomal storage disorder (LSD). This review summarizes the current knowledge related to this protein and the rest of the mucolipin family.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Humans
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Lysosomes / genetics
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Lysosomes / metabolism
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Lysosomes / physiology*
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Models, Biological
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Protein Binding
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Protein Transport
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TRPM Cation Channels / genetics
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TRPM Cation Channels / metabolism
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TRPM Cation Channels / physiology*
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Transient Receptor Potential Channels / genetics
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Transient Receptor Potential Channels / metabolism
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Transient Receptor Potential Channels / physiology*
Substances
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MCOLN1 protein, human
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MCOLN3 protein, human
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Mcoln2 protein, human
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TRPM Cation Channels
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Transient Receptor Potential Channels