Switching gears: translational mastery of transcription during memory formation

Charles A Hoeffer; Eric Klann

doi:10.1016/j.neuron.2007.04.003

Switching gears: translational mastery of transcription during memory formation

Neuron. 2007 Apr 19;54(2):186-9. doi: 10.1016/j.neuron.2007.04.003.

Authors

Charles A Hoeffer¹, Eric Klann

Affiliation

¹ Center for Neural Science, New York University, New York, NY 10003, USA.

PMID: 17442240
DOI: 10.1016/j.neuron.2007.04.003

Abstract

A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these persistent neuronal changes under translational control mediated by eIF2alpha.

MeSH terms

Activating Transcription Factor 4 / physiology
Animals
Cyclic AMP Response Element-Binding Protein / physiology
Eukaryotic Initiation Factor-2 / genetics
Eukaryotic Initiation Factor-2 / physiology
Humans
Memory / physiology*
Memory, Short-Term / physiology
Mice
Mice, Knockout
Nerve Tissue Proteins / biosynthesis
Neuronal Plasticity / physiology
Phosphorylation
Protein Biosynthesis / physiology*
RNA, Messenger / biosynthesis*

Substances

Atf4 protein, mouse
Cyclic AMP Response Element-Binding Protein
Eukaryotic Initiation Factor-2
Nerve Tissue Proteins
RNA, Messenger
Activating Transcription Factor 4