Abstract
A critical molecular requirement underlying many forms of long-lasting synaptic plasticity and memory is the de novo synthesis of mRNAs and proteins. In a recent paper in Cell, Costa-Mattioli et al. present data from a pharmacogenetic study that places a key regulatory event in the "neural decision" to undergo these persistent neuronal changes under translational control mediated by eIF2alpha.
MeSH terms
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Activating Transcription Factor 4 / physiology
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Animals
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Cyclic AMP Response Element-Binding Protein / physiology
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Eukaryotic Initiation Factor-2 / genetics
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Eukaryotic Initiation Factor-2 / physiology
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Humans
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Memory / physiology*
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Memory, Short-Term / physiology
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Mice
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Mice, Knockout
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Nerve Tissue Proteins / biosynthesis
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Neuronal Plasticity / physiology
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Phosphorylation
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Protein Biosynthesis / physiology*
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RNA, Messenger / biosynthesis*
Substances
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Atf4 protein, mouse
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Cyclic AMP Response Element-Binding Protein
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Eukaryotic Initiation Factor-2
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Nerve Tissue Proteins
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RNA, Messenger
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Activating Transcription Factor 4