Two new non-competitive mGlu1 receptor antagonists are potent tools to unravel functions of this mGlu receptor subtype

T Knöpfel

doi:10.1038/sj.bjp.0707289

Two new non-competitive mGlu1 receptor antagonists are potent tools to unravel functions of this mGlu receptor subtype

Br J Pharmacol. 2007 Jul;151(6):723-4. doi: 10.1038/sj.bjp.0707289. Epub 2007 May 14.

Author

T Knöpfel¹

Affiliation

¹ Laboratory for Neuronal Circuit Dynamics, RIKEN BSI, Wako-shi, Saitama, Japan. tknopfel@brain.riken.jp

Abstract

The validation of the selective, potent and systemically active non-competitive mGlu1 antagonists YM-298198 and JNJ16259685 in a physiological functional assay will facilitate elucidation of this receptor's role in brain function and as a potential drug target.

MeSH terms

Benzimidazoles / pharmacology*
Brain / physiology
Drug Delivery Systems
Electrophysiology
Humans
Quinolines / pharmacology*
Receptors, Metabotropic Glutamate / antagonists & inhibitors*
Receptors, Metabotropic Glutamate / physiology
Synaptic Transmission
Thiazoles / pharmacology*

Substances

(3,4-dihydro-2H-pyrano(2,3)b-quinolin-7-yl)-(cis-4-methoxycyclohexyl) methanone
6-amino-N-cyclohexyl-N,3-dimethylthiazolo(3,2-a)benzimidazole-2-carboxamide
Benzimidazoles
Quinolines
Receptors, Metabotropic Glutamate
Thiazoles
metabotropic glutamate receptor type 1