Abstract
Addicts and drug-experienced animals have decision-making deficits in reversal-learning tasks and more complex 'gambling' variants. Here we show evidence that these deficits are mediated by persistent encoding of outdated associative information in the basolateral amygdala. Cue-selective neurons in the basolateral amygdala, recorded in cocaine-treated rats, failed to change cue preference during reversal learning. Further, the presence of these neurons was critical to the expression of the reversal-learning deficit in the cocaine-treated rats.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Action Potentials / drug effects
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Amygdala / cytology
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Amygdala / drug effects*
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Animals
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Behavior, Animal
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Cocaine / administration & dosage*
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Cocaine-Related Disorders / etiology
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Cocaine-Related Disorders / physiopathology*
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Cues
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Decision Making / drug effects*
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Discrimination, Psychological / drug effects
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Disease Models, Animal
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Dopamine Uptake Inhibitors / administration & dosage*
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Dose-Response Relationship, Drug
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Excitatory Amino Acid Agonists / administration & dosage
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Male
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Motor Activity / drug effects
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N-Methylaspartate / administration & dosage
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Neurons / drug effects
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Odorants
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Rats
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Rats, Long-Evans
Substances
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Dopamine Uptake Inhibitors
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Excitatory Amino Acid Agonists
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N-Methylaspartate
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Cocaine