Abstract
Instrumental conditioning allows animals to learn about the consequences of their own actions, but the underpinning molecular mechanisms remain elusive. Here we show that the sphingosine-1-phosphate (S1P) receptor Gpr6 is selectively expressed in the striatopallidal neurons in the striatum. Gpr6-deficient mice showed reduced striatal cyclic AMP production in vitro and selective alterations in instrumental conditioning in vivo. Thus, Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Analysis of Variance
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Animals
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Behavior, Animal / physiology
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Colforsin / pharmacology
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Conditioning, Operant / physiology*
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Cyclic AMP / metabolism
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Food Deprivation
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Gene Expression Regulation / drug effects
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Gene Expression Regulation / physiology*
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Globus Pallidus / cytology*
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Green Fluorescent Proteins / metabolism
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Mice
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Mice, Knockout
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Mutation
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Neurons / drug effects
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Neurons / metabolism*
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Reaction Time / genetics
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Receptors, Lysosphingolipid / deficiency
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Receptors, Lysosphingolipid / metabolism*
Substances
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Receptors, Lysosphingolipid
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Green Fluorescent Proteins
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Colforsin
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Cyclic AMP