Abstract
We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amyotrophic Lateral Sclerosis / genetics*
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Case-Control Studies
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Chromosomes, Human, Pair 7
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
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Genetic Predisposition to Disease*
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Humans
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Nerve Tissue Proteins / genetics*
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Peptide Hydrolases / genetics*
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Polymorphism, Single Nucleotide
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Potassium Channels / genetics*
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White People / genetics
Substances
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Nerve Tissue Proteins
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Potassium Channels
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DPP6 protein, human
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Peptide Hydrolases
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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases