Abstract
Wiring the vertebrate nervous system is a multi-step process that relies heavily upon the role of transmembrane and extracellular adhesion molecules. Despite the extensive attention focused on such molecules, collagens, a large family of structural adhesion molecules expressed in the vertebrate nervous system, have been largely overlooked for roles in neural circuit formation. Recently, however, several studies have unexpectedly identified novel roles of collagens and collagen-like molecules in the developing vertebrate nervous system. Here, contributions of these collagens and collagen-like molecules in neural circuit formation are reviewed.
MeSH terms
-
Animals
-
Axons / physiology
-
Axons / ultrastructure
-
Cell Adhesion Molecules / metabolism
-
Cell Differentiation / physiology
-
Central Nervous System* / anatomy & histology
-
Central Nervous System* / physiology
-
Collagen / chemistry
-
Collagen / genetics
-
Collagen / metabolism*
-
Extracellular Matrix / chemistry
-
Extracellular Matrix / metabolism
-
Glycosyltransferases / genetics
-
Glycosyltransferases / metabolism
-
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase / genetics
-
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase / metabolism
-
Protein Isoforms / chemistry
-
Protein Isoforms / genetics
-
Protein Isoforms / metabolism*
-
Synapses / metabolism
-
Synapses / ultrastructure
-
Zebrafish Proteins / genetics
-
Zebrafish Proteins / metabolism
Substances
-
Cell Adhesion Molecules
-
Protein Isoforms
-
Zebrafish Proteins
-
plod3 protein, zebrafish
-
Collagen
-
Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase
-
Glycosyltransferases