Abstract
The effects of MPTP on two mouse strains with different MPTP sensitivities and immunological backgrounds were compared: MPTP-sensitive C57BL/6 mice (B6) with a propensity for Th1 and less MPTP-sensitive BALB/c mice (BALB) with a propensity for Th2. It was found that acute MPTP treatment induced behavioral dysfunction, activated microglia/astrocytes, and increased the levels of IL-10, IL-12(p40) IL-13, IFN-gamma, and MCP-1 in CSF in B6, but not in BALB. This suggests that variances in immunological backgrounds might be a major contributing factor in sensitivity differences to MPTP.
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / pharmacology*
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Analysis of Variance
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Animals
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Astrocytes / drug effects*
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism
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Cytokines / blood*
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Cytokines / cerebrospinal fluid*
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Drug Administration Schedule
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Male
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Mice
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Mice, Inbred Strains
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Microglia / drug effects*
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Movement / drug effects
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Nerve Growth Factors / metabolism
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Neurotoxins / pharmacology*
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S100 Calcium Binding Protein beta Subunit
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S100 Proteins / metabolism
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Species Specificity
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Time Factors
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Tyrosine 3-Monooxygenase / metabolism
Substances
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Cytokines
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Nerve Growth Factors
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Neurotoxins
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S100 Calcium Binding Protein beta Subunit
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S100 Proteins
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Tyrosine 3-Monooxygenase