Biochemical and functional properties of the store-operated Ca2+ channels

Cell Signal. 2009 Apr;21(4):457-61. doi: 10.1016/j.cellsig.2008.11.005. Epub 2008 Nov 13.

Abstract

Store-operated calcium entry (SOCE) is a major mechanism for Ca(2+) entry in excitable and non-excitable cells. The best-characterised store-operated current is I(CRAC), but other currents activated by Ca(2+) store depletion have also been reported. The recent identification of the proteins stromal interaction molecule 1 (STIM1) and Orai1 has shed new light on the nature and regulation of SOC channels. STIM1 has been presented as the endoplasmic reticulum (ER) Ca(2+) sensor that communicates the content of the Ca(2+) stores to the store-operated channels, a mechanism that involves redistribution of STIM1 to peripheral ER sites and co-clustering with the Ca(2+) channel subunit, Orai1. Interestingly, TRPC1, which has long been proposed as a SOC channel candidate, associates with Orai1 and STIM1 in a ternary complex that appears to increase the variability of SOC currents available to modulate cell function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium Channels / classification
  • Calcium Channels / deficiency
  • Calcium Channels / genetics
  • Calcium Channels / physiology*
  • Calcium Signaling / drug effects
  • Calcium Signaling / physiology*
  • Cations / metabolism
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / physiology
  • Drosophila Proteins / genetics
  • Drosophila Proteins / physiology
  • Humans
  • Ion Transport / drug effects
  • Ion Transport / physiology
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / physiology
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / physiology
  • ORAI1 Protein
  • ORAI2 Protein
  • Protein Interaction Mapping
  • Protein Multimerization
  • Severe Combined Immunodeficiency / genetics
  • Stromal Interaction Molecule 1
  • Stromal Interaction Molecule 2
  • TRPC Cation Channels / classification
  • TRPC Cation Channels / genetics
  • TRPC Cation Channels / physiology
  • Thapsigargin / pharmacology

Substances

  • Calcium Channels
  • Cations
  • Cell Adhesion Molecules
  • Drosophila Proteins
  • Membrane Proteins
  • Multiprotein Complexes
  • Neoplasm Proteins
  • ORAI1 Protein
  • ORAI1 protein, human
  • ORAI2 Protein
  • ORAI2 protein, human
  • Orai3 protein, human
  • STIM1 protein, human
  • STIM2 protein, human
  • Stromal Interaction Molecule 1
  • Stromal Interaction Molecule 2
  • TRPC Cation Channels
  • olf186-F protein, Drosophila
  • Thapsigargin
  • Calcium