Abstract
Store-operated calcium entry (SOCE) is a major mechanism for Ca(2+) entry in excitable and non-excitable cells. The best-characterised store-operated current is I(CRAC), but other currents activated by Ca(2+) store depletion have also been reported. The recent identification of the proteins stromal interaction molecule 1 (STIM1) and Orai1 has shed new light on the nature and regulation of SOC channels. STIM1 has been presented as the endoplasmic reticulum (ER) Ca(2+) sensor that communicates the content of the Ca(2+) stores to the store-operated channels, a mechanism that involves redistribution of STIM1 to peripheral ER sites and co-clustering with the Ca(2+) channel subunit, Orai1. Interestingly, TRPC1, which has long been proposed as a SOC channel candidate, associates with Orai1 and STIM1 in a ternary complex that appears to increase the variability of SOC currents available to modulate cell function.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calcium / metabolism
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Calcium Channels / classification
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Calcium Channels / deficiency
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Calcium Channels / genetics
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Calcium Channels / physiology*
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Calcium Signaling / drug effects
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Calcium Signaling / physiology*
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Cations / metabolism
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Cell Adhesion Molecules / genetics
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Cell Adhesion Molecules / physiology
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Drosophila Proteins / genetics
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Drosophila Proteins / physiology
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Humans
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Ion Transport / drug effects
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Ion Transport / physiology
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Membrane Proteins / genetics
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Membrane Proteins / physiology
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Multiprotein Complexes / chemistry
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Multiprotein Complexes / physiology
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology
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ORAI1 Protein
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ORAI2 Protein
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Protein Interaction Mapping
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Protein Multimerization
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Severe Combined Immunodeficiency / genetics
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Stromal Interaction Molecule 1
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Stromal Interaction Molecule 2
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TRPC Cation Channels / classification
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TRPC Cation Channels / genetics
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TRPC Cation Channels / physiology
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Thapsigargin / pharmacology
Substances
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Calcium Channels
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Cations
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Cell Adhesion Molecules
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Drosophila Proteins
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Membrane Proteins
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Multiprotein Complexes
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Neoplasm Proteins
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ORAI1 Protein
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ORAI1 protein, human
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ORAI2 Protein
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ORAI2 protein, human
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Orai3 protein, human
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STIM1 protein, human
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STIM2 protein, human
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Stromal Interaction Molecule 1
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Stromal Interaction Molecule 2
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TRPC Cation Channels
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olf186-F protein, Drosophila
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Thapsigargin
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Calcium