Abstract
Repeated forced swim resulted in a decrease in the concentrations of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid in the hypothalamus and amygdala 24 h after the second swim session. This stressor also increased the mRNA levels for tryptophan hydroxylase-2, the rate-limiting enzyme in neuronal 5-HT synthesis, and 5-HT transporter in the midbrain as well as 5-HT1A receptor in the frontal cortex. Some of these serotonergic changes may be involved in the mechanisms of a depressive-like behavior induced by a stress of repeated swim in these animals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Behavior, Animal / physiology*
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Brain / anatomy & histology
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Brain / metabolism
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Depression / metabolism
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Male
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Physical Exertion / physiology*
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Rats
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Rats, Wistar
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Receptor, Serotonin, 5-HT1A / genetics
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Receptor, Serotonin, 5-HT1A / metabolism
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Serotonin / metabolism*
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Serotonin Plasma Membrane Transport Proteins / genetics
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Serotonin Plasma Membrane Transport Proteins / metabolism
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Stress, Psychological*
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Swimming
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Tryptophan Hydroxylase / genetics
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Tryptophan Hydroxylase / metabolism
Substances
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Serotonin Plasma Membrane Transport Proteins
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Slc6a4 protein, rat
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Receptor, Serotonin, 5-HT1A
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Serotonin
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Tryptophan Hydroxylase
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tph2 protein, rat