Abstract
The APP-processing pathway is a pathological component of Alzheimer's disease (AD), but there is no consensus regarding the physiological functions of APP and its products. Two studies (Nikolaev et al., 2009; Lauren et al., 2009) link the physiological and pathological aspects of APP processing. They show that the APP products, N-APP and Abeta42, are ligands for death receptor 6 and cellular prion protein, respectively, which are important in nervous system development and synaptic suppression.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alzheimer Disease / pathology*
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Alzheimer Disease / physiopathology*
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Amyloid beta-Peptides / metabolism
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Amyloid beta-Protein Precursor / metabolism
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Animals
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Humans
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Peptide Fragments / metabolism
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PrPC Proteins / metabolism
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Receptors, Tumor Necrosis Factor / metabolism
Substances
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor
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Peptide Fragments
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PrPC Proteins
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Receptors, Tumor Necrosis Factor
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amyloid beta-protein (1-42)