Abstract
Breathing relies on a respiratory rhythm generator. A study characterizes an early emerging oscillatory group of Phox2b-expressing parafacial cells that entrain and couple with the preBötzinger Complex at the onset of fetal breathing.
MeSH terms
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Animals
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Biological Clocks / physiology*
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Biological Evolution
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Brain Stem / embryology*
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Brain Stem / metabolism
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Early Growth Response Protein 2 / metabolism
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Homeodomain Proteins / metabolism
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Humans
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Mice
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Nerve Net / embryology*
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Nerve Net / metabolism
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Neurogenesis / physiology
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Neurons / cytology
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Neurons / metabolism
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Receptors, Neurokinin-1 / metabolism
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Respiratory Center / embryology*
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Respiratory Center / metabolism
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Respiratory Physiological Phenomena*
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Stem Cells / cytology
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Stem Cells / metabolism
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Transcription Factors / metabolism
Substances
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Early Growth Response Protein 2
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Egr2 protein, mouse
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Homeodomain Proteins
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NBPhox protein
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Receptors, Neurokinin-1
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Transcription Factors