Abstract
A study in this issue of Molecular Cell (Elcheva et al., 2009) shows the inherent instability of the betaTrCP1 mRNA to be caused by microRNA-183 targeting the coding sequence; interestingly, this action is directly opposed by the RNA-binding protein CRD-BP.
MeSH terms
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Argonaute Proteins
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Binding Sites
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Eukaryotic Initiation Factor-2 / metabolism
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Humans
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MicroRNAs / metabolism
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MicroRNAs / physiology*
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Models, Genetic
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RNA Stability / physiology*
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RNA, Messenger / chemistry
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RNA, Messenger / metabolism*
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RNA-Binding Proteins / physiology
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beta-Transducin Repeat-Containing Proteins / genetics
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beta-Transducin Repeat-Containing Proteins / metabolism
Substances
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AGO2 protein, human
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Argonaute Proteins
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BTRC protein, human
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Eukaryotic Initiation Factor-2
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IGF2BP1 protein, human
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MIRN183 microRNA, human
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MicroRNAs
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RNA, Messenger
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RNA-Binding Proteins
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beta-Transducin Repeat-Containing Proteins