Abstract
Gemfibrozil is long known for its ability to reduce the level of triglycerides in the blood circulation and to decrease the risk of hyperlipidemia. However, a number of recent studies reveal that apart from its lipid-lowering effects, gemfibrozil can also regulate many other signaling pathways responsible for inflammation, switching of T-helper cells, cell-to-cell contact, migration, and oxidative stress. In this review, we have made an honest attempt to analyze various biological activities of gemfibrozil and associated mechanisms that may help to consider this drug for different human disorders as primary or adjunct therapy.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Cell Communication / drug effects*
-
Cell Communication / immunology
-
Cell Movement / drug effects*
-
Cell Movement / immunology
-
Gemfibrozil / pharmacology*
-
Gemfibrozil / therapeutic use
-
Humans
-
Hyperlipidemias / blood
-
Hyperlipidemias / immunology
-
Hyperlipidemias / prevention & control
-
Hypolipidemic Agents / pharmacology*
-
Hypolipidemic Agents / therapeutic use
-
Inflammation / blood
-
Inflammation / immunology
-
Oxidative Stress / drug effects*
-
Oxidative Stress / immunology
-
Signal Transduction / drug effects*
-
Signal Transduction / immunology
-
T-Lymphocytes, Helper-Inducer / immunology*
-
Triglycerides / blood
-
Triglycerides / immunology
Substances
-
Hypolipidemic Agents
-
Triglycerides
-
Gemfibrozil