Abstract
The transcriptional program that controls adult neurogenesis is unknown. We generated mice with an inducible stem cell-specific deletion of Neurod1, resulting in substantially fewer newborn neurons in the hippocampus and olfactory bulb. Thus, Neurod1 is cell-intrinsically required for the survival and maturation of adult-born neurons.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult Stem Cells / physiology*
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Animals
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Astrocytes / physiology
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Basic Helix-Loop-Helix Transcription Factors / genetics
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Basic Helix-Loop-Helix Transcription Factors / metabolism*
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Cell Differentiation / physiology
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Cell Survival / physiology
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Cells, Cultured
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Hippocampus / physiology*
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Mice
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Mice, Knockout
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Mice, Transgenic
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Neurogenesis / physiology*
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Neurons / physiology*
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Olfactory Bulb / physiology*
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Time Factors
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Neurod1 protein, mouse