NMDA-dependent induction of long-term potentiation in afferent and association fiber systems of piriform cortex in vitro

E D Kanter; L B Haberly

doi:10.1016/0006-8993(90)91337-g

NMDA-dependent induction of long-term potentiation in afferent and association fiber systems of piriform cortex in vitro

Brain Res. 1990 Aug 13;525(1):175-9. doi: 10.1016/0006-8993(90)91337-g.

Authors

E D Kanter¹, L B Haberly

Affiliation

¹ Neuroscience Training Program, University of Wisconsin, Madison 53706.

PMID: 1978790
DOI: 10.1016/0006-8993(90)91337-g

Abstract

Long-term potentiation (LTP) was demonstrated in a slice preparation of piriform (olfactory) cortex. LTP could be reliably induced in both afferent and association fiber pathways. The magnitude of the observed potentiation was greater in the association fiber pathway. 2-Amino-5-phosphonovalerate (APV) blocked induction of LTP in both pathways, indicating that N-methyl-D-aspartate (NMDA) receptor activation is required for induction.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

2-Amino-5-phosphonovalerate / pharmacology
Afferent Pathways / physiology
Animals
Cerebral Cortex / physiology*
Electric Stimulation
Evoked Potentials / physiology
In Vitro Techniques
Nerve Fibers / physiology*
Rats
Receptors, N-Methyl-D-Aspartate / drug effects
Receptors, N-Methyl-D-Aspartate / physiology*
Time Factors

Substances

Receptors, N-Methyl-D-Aspartate
2-Amino-5-phosphonovalerate

Grants and funding

NS19865/NS/NINDS NIH HHS/United States