Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system

Małgorzata Filip; Michael Bader

doi:10.1016/s1734-1140(09)70132-x

Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system

Pharmacol Rep. 2009 Sep-Oct;61(5):761-77. doi: 10.1016/s1734-1140(09)70132-x.

Authors

Małgorzata Filip¹, Michael Bader

Affiliation

¹ Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland. filip@if-pan.krakow.pl

PMID: 19903999
DOI: 10.1016/s1734-1140(09)70132-x

Abstract

The present review gives an overview on the serotonin (5-hydroxytryptamine; 5-HT) system, its receptors and their relationship to central nervous system physiology and disorders. Additionally, we also introduce the recent knowledge about the 5-HT receptor ligands in preclinical research, clinical trials and as approved drugs.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Central Nervous System / physiology
Central Nervous System / physiopathology
Central Nervous System Diseases / drug therapy*
Central Nervous System Diseases / physiopathology
Clinical Trials as Topic
Drug Evaluation, Preclinical
Humans
Ligands
Receptors, Serotonin / drug effects
Receptors, Serotonin / metabolism*
Serotonin / metabolism*

Substances

Ligands
Receptors, Serotonin
Serotonin