Abstract
Genome-wide association studies (GWAS) have uncovered over two dozen candidate Alzheimer disease susceptibility genes; however, the results of these studies showed limited overlap. Two independently performed GWAS involving cohorts from europe and the US have now identified three additional putative Alzheimer disease genes that show modest but remarkably consistent effects across data sets.
MeSH terms
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Alzheimer Disease / genetics*
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Clusterin / genetics*
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Genetic Predisposition to Disease*
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Genome-Wide Association Study
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Humans
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Monomeric Clathrin Assembly Proteins / genetics
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Multicenter Studies as Topic
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Receptors, Complement 3b / genetics
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Risk Factors
Substances
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CLU protein, human
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CR1 protein, human
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Clusterin
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Monomeric Clathrin Assembly Proteins
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PICALM protein, human
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Receptors, Complement 3b