PTEN/mTOR and axon regeneration

Kevin K Park; Kai Liu; Yang Hu; Jennifer L Kanter; Zhigang He

doi:10.1016/j.expneurol.2009.12.032

PTEN/mTOR and axon regeneration

Exp Neurol. 2010 May;223(1):45-50. doi: 10.1016/j.expneurol.2009.12.032. Epub 2010 Jan 14.

Authors

Kevin K Park¹, Kai Liu, Yang Hu, Jennifer L Kanter, Zhigang He

Affiliation

¹ F.M. Kirby Neurobiology Center, Children's Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. kevin.park@childrens.harvard.edu

PMID: 20079353
DOI: 10.1016/j.expneurol.2009.12.032

Abstract

How axon regeneration is controlled in both PNS and CNS remains elusive. Mechanistic studies of axon growth during development and axon regeneration after injury reveal the PTEN dependent molecular mechanism as a commonality. This pathway could impact the processes occurring in the neuronal soma, such as mTOR-regulated protein translation, and in the axons, such as cytoskeleton assembly. In this review, we will discuss the current understanding of the involvement of these processes in the regulation of axon growth and the potential implication in promoting axon regeneration after injury.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Axons / metabolism*
Humans
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / metabolism*
Models, Biological
Nerve Regeneration / physiology*
PTEN Phosphohydrolase / genetics
PTEN Phosphohydrolase / metabolism*
Peripheral Nervous System Diseases / metabolism*
Peripheral Nervous System Diseases / physiopathology*
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / metabolism*
Signal Transduction / physiology
TOR Serine-Threonine Kinases

Substances

Intracellular Signaling Peptides and Proteins
MTOR protein, human
Protein Serine-Threonine Kinases
TOR Serine-Threonine Kinases
PTEN Phosphohydrolase