Keeping them quiet: BMPs maintain adult neural stem cell quiescence

Mantissa A Johnston; Daniel A Lim

doi:10.1016/j.stem.2010.06.006

Keeping them quiet: BMPs maintain adult neural stem cell quiescence

Cell Stem Cell. 2010 Jul 2;7(1):9-10. doi: 10.1016/j.stem.2010.06.006.

Authors

Mantissa A Johnston¹, Daniel A Lim

Affiliation

¹ Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, M779, San Francisco, CA 94143, USA.

PMID: 20621042
DOI: 10.1016/j.stem.2010.06.006

Abstract

Neural stem cells (NSCs) in the adult dentate gyrus divide relatively infrequently, a trait that may prevent premature NSC depletion. In this issue of Cell Stem Cell, Mira et al. (2010) demonstrate that BMP signaling regulates the quiescence of dentate gyrus NSCs, restraining their proliferation to maintain long-term adult neurogenesis.

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