Abstract
Parvalbumin-expressing, fast-spiking basket cells are important for the generation of synchronous, rhythmic population activities in the hippocampus. We found that GABAA receptor-mediated synaptic inputs from murine parvalbumin-expressing basket cells were selectively modulated by the membrane voltage- and intracellular chloride-dependent chloride channel ClC-2. Our data reveal a previously unknown cell type-specific regulation of intracellular chloride homeostasis in the perisomatic region of hippocampal pyramidal neurons.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / physiology*
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Animals
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Axons / physiology
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CLC-2 Chloride Channels
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Chloride Channels / metabolism*
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Chlorides / metabolism
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Cholecystokinin / metabolism
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Hippocampus / physiology*
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Homeostasis
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In Vitro Techniques
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Inhibitory Postsynaptic Potentials / physiology
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Interneurons / physiology
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Intracellular Space / metabolism
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Membrane Potentials / physiology
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Mice
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Neurons / physiology*
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Parvalbumins / metabolism
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Pyramidal Cells / physiology*
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Rats
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Rats, Sprague-Dawley
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Receptors, GABA-A / metabolism
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Synapses / physiology*
Substances
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CLC-2 Chloride Channels
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Chloride Channels
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Chlorides
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Parvalbumins
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Receptors, GABA-A
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Cholecystokinin