Abstract
Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function. To test this idea directly, we functionally removed parvalbumin-positive interneurons selectively from hippocampal CA1 in mice. We found that parvalbumin-positive interneurons are dispensable for spatial reference, but are essential for spatial working memory.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Behavior, Animal / physiology
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Hippocampus / physiology*
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Interneurons / physiology*
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Memory, Short-Term / physiology*
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Metalloendopeptidases / genetics
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Metalloendopeptidases / metabolism
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Mice
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Neuropsychological Tests
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Parvalbumins / metabolism*
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Space Perception / physiology
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Tetanus Toxin / genetics
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Tetanus Toxin / metabolism
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Vesicle-Associated Membrane Protein 2 / genetics
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Vesicle-Associated Membrane Protein 2 / metabolism
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gamma-Aminobutyric Acid / metabolism
Substances
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Parvalbumins
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Recombinant Fusion Proteins
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Tetanus Toxin
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Vesicle-Associated Membrane Protein 2
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vesicle-associated membrane protein 2, mouse
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gamma-Aminobutyric Acid
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Metalloendopeptidases
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zinc-endopeptidase, tetanus neurotoxin