Dopaminergic control of the striatum for high-level cognition

Roshan Cools

doi:10.1016/j.conb.2011.04.002

Dopaminergic control of the striatum for high-level cognition

Curr Opin Neurobiol. 2011 Jun;21(3):402-7. doi: 10.1016/j.conb.2011.04.002. Epub 2011 Apr 29.

Author

Roshan Cools¹

Affiliation

¹ Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging & Department of Psychiatry, Nijmegen, The Netherlands. roshan.cools@gmail.com

PMID: 21531543
DOI: 10.1016/j.conb.2011.04.002

Abstract

Dopamine has long been implicated in a wide variety of high-level cognitive processes, ranging from working memory to rule learning and attention switching. Notable progress has been made in the past decades, but the mechanisms underlying effects of dopamine on high-level cognition remain unclear. This article reviews evidence for an important role of the striatum and its interaction with the prefrontal cortex and suggests a variety of ways by which changes in dopamine transmission can bias high-level cognition.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cognition / physiology*
Corpus Striatum / physiology*
Dopamine / metabolism*
Humans
Models, Biological

Substances

Dopamine