Abstract
The thalamic reticular nucleus (TRN) is hypothesized to regulate neocortical rhythms and behavioral states. Using optogenetics and multi-electrode recording in behaving mice, we found that brief selective drive of TRN switched the thalamocortical firing mode from tonic to bursting and generated state-dependent neocortical spindles. These findings provide causal support for the involvement of the TRN in state regulation in vivo and introduce a new model for addressing the role of this structure in behavior.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Action Potentials / physiology*
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Animals
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Bacterial Proteins / genetics
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Brain Mapping
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Channelrhodopsins
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Electroencephalography / methods
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Electromyography
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Evoked Potentials, Somatosensory / physiology*
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Glutamate Decarboxylase / metabolism
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Imaging, Three-Dimensional
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Light
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Luminescent Proteins / genetics
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Microscopy, Confocal
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Neural Pathways / physiology
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Neurons / physiology*
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Optical Devices*
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Patch-Clamp Techniques
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Somatosensory Cortex / cytology
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Somatosensory Cortex / physiology*
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Thalamic Nuclei / cytology
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Thalamic Nuclei / physiology*
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Vesicular Inhibitory Amino Acid Transport Proteins / genetics
Substances
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Bacterial Proteins
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Channelrhodopsins
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Luminescent Proteins
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Vesicular Inhibitory Amino Acid Transport Proteins
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Viaat protein, mouse
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yellow fluorescent protein, Bacteria
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Glutamate Decarboxylase
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glutamate decarboxylase 1