Abstract
Depolarization by the neurotransmitter GABA regulates adult neurogenesis. We found interneurons of the neurogliaform cell family to be a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurred in concert with reduced synaptic inhibition of mature neurons, suggesting that the local circuitry coordinates the activation of new and pre-existing cells.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Action Potentials / drug effects
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Action Potentials / genetics
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Animals
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Animals, Newborn
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Bacterial Proteins / genetics
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Biophysical Phenomena / drug effects
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Biophysical Phenomena / genetics
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Cell Adhesion Molecules, Neuronal / metabolism
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Electric Stimulation / methods
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Excitatory Amino Acid Antagonists / pharmacology
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Extracellular Matrix Proteins / metabolism
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GABA Antagonists / pharmacology
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Glutamic Acid / pharmacology
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Green Fluorescent Proteins / genetics
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Interneurons / drug effects
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Interneurons / physiology*
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Iontophoresis / methods
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Luminescent Proteins / genetics
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Lysine / analogs & derivatives
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Lysine / metabolism
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Models, Neurological
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Nerve Net / drug effects
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Nerve Net / physiology
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Nerve Tissue Proteins / metabolism
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Neural Inhibition / drug effects
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Neural Inhibition / genetics
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Neural Inhibition / physiology*
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Neurogenesis / drug effects
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Neurogenesis / genetics
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Neurogenesis / physiology*
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Neuropeptide Y / genetics
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Neuropeptide Y / metabolism
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Nitric Oxide Synthase Type I / metabolism
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Patch-Clamp Techniques
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Picrotoxin / pharmacology
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Pro-Opiomelanocortin / genetics
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Pro-Opiomelanocortin / metabolism
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Quinoxalines / pharmacology
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Reelin Protein
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Serine Endopeptidases / metabolism
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Stem Cell Niche / drug effects
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Stem Cell Niche / genetics
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Stem Cell Niche / physiology*
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Synaptic Potentials / drug effects
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Synaptic Potentials / genetics
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Time Factors
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Valine / analogs & derivatives
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Valine / pharmacology
Substances
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Bacterial Proteins
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Cell Adhesion Molecules, Neuronal
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Excitatory Amino Acid Antagonists
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Extracellular Matrix Proteins
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GABA Antagonists
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Luminescent Proteins
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Nerve Tissue Proteins
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Neuropeptide Y
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Quinoxalines
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Reelin Protein
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enhanced green fluorescent protein
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yellow fluorescent protein, Bacteria
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2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
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Picrotoxin
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Green Fluorescent Proteins
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Glutamic Acid
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Pro-Opiomelanocortin
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2-amino-5-phosphopentanoic acid
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Nitric Oxide Synthase Type I
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Serine Endopeptidases
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biocytin
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Valine
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Lysine