Abstract
Just over 2 years ago, TET1 was found to catalyse the oxidation of 5-methylcytosine, a well-known epigenetic mark, into 5-hydroxymethylcytosine in mammalian DNA. The exciting prospect of a novel epigenetic modification that may dynamically regulate DNA methylation has led to the rapid accumulation of publications from a wide array of fields, from biochemistry to stem cell biology. Although we have only started to scratch the surface, interesting clues on the role of 5-hydroxymethylcytosine are quickly emerging.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
5-Methylcytosine / metabolism
-
Animals
-
Blastocyst Inner Cell Mass / metabolism
-
Cell Differentiation / genetics
-
Cell Proliferation
-
Chromatin / metabolism
-
CpG Islands / physiology
-
Cytosine / analogs & derivatives*
-
Cytosine / metabolism
-
DNA / genetics
-
DNA / metabolism
-
DNA Methylation / genetics
-
DNA-Binding Proteins* / genetics
-
DNA-Binding Proteins* / metabolism
-
Deamination / genetics
-
Dioxygenases
-
Embryonic Stem Cells / cytology
-
Embryonic Stem Cells / enzymology
-
Epigenesis, Genetic / genetics*
-
Epigenomics / methods*
-
Gene Expression Regulation, Developmental
-
Gene Silencing / physiology
-
Genome / genetics
-
Hematopoiesis / genetics
-
Humans
-
Mice
-
Mice, Knockout
-
Mixed Function Oxygenases
-
Proto-Oncogene Proteins* / genetics
-
Proto-Oncogene Proteins* / metabolism
-
Tissue Distribution / genetics
Substances
-
Chromatin
-
DNA-Binding Proteins
-
Proto-Oncogene Proteins
-
TET1 protein, mouse
-
5-hydroxymethylcytosine
-
5-Methylcytosine
-
Cytosine
-
DNA
-
Mixed Function Oxygenases
-
TET1 protein, human
-
Dioxygenases
-
TET2 protein, human
-
Tet2 protein, mouse
-
Tet3 protein, mouse