Correlation of Aβ deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease

Naoko Kameshima; Toshifumi Nanjou; Takaomi Fukuhara; Daijiro Yanagisawa; Ikuo Tooyama

doi:10.1016/j.neulet.2012.02.026

Correlation of Aβ deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer's disease

Neurosci Lett. 2012 Apr 4;513(2):166-9. doi: 10.1016/j.neulet.2012.02.026. Epub 2012 Feb 17.

Authors

Naoko Kameshima¹, Toshifumi Nanjou, Takaomi Fukuhara, Daijiro Yanagisawa, Ikuo Tooyama

Affiliation

¹ Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu 520-2192, Japan.

PMID: 22343315
DOI: 10.1016/j.neulet.2012.02.026

Abstract

The deposition of β-amyloid peptides (Aβ) is commonly reported in the nasal cavity of Alzheimer's disease (AD) patients, although the pathological significance of this finding is unknown. This study compared Aβ concentrations in the nasal area with those in the brain, blood, and cerebrospinal fluid, respectively. Immunohistochemical analysis identified Aβ deposits in the nasal epithelium of Tg2576 mice. Enzyme-linked immunosorbent assay measurements revealed a correlation between the content of Aβ42 in the nasal area and that in the brain, but not with that in the blood. These results suggest that the highly accessible nasal cavity could be a useful site for diagnostic analysis of AD based on Aβ content.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / metabolism
Alzheimer Disease / pathology*
Amyloid beta-Peptides / metabolism*
Animals
Brain / metabolism
Brain / pathology*
Disease Models, Animal
Disease Progression
Mice
Mice, Transgenic
Nasal Cavity / metabolism
Nasal Cavity / pathology*
Plaque, Amyloid / metabolism
Plaque, Amyloid / pathology*

Substances

Amyloid beta-Peptides