Abstract
The mechanism of brain reorganization in pain chronification is unknown. In a longitudinal brain imaging study, subacute back pain (SBP) patients were followed over the course of 1 year. When pain persisted (SBPp, in contrast to recovering SBP and healthy controls), brain gray matter density decreased. Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Pain / physiopathology
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Adult
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Back Pain / physiopathology*
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Biomarkers
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Brain / pathology
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Brain / physiopathology*
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Chronic Pain / physiopathology
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Corpus Striatum / physiopathology
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Female
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Follow-Up Studies
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Forecasting / methods
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Humans
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Magnetic Resonance Imaging / methods
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Male
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Neural Pathways / physiopathology
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Nucleus Accumbens / physiopathology
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Pain Measurement / instrumentation
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Prefrontal Cortex / physiopathology