Abstract
Despite the prevailing idea that neurogliaform cells produce a spatially unrestricted widespread inhibition, we demonstrate here that their activity attenuates thalamic-evoked feed-forward inhibition in layer IV barrel cortex but has no effect on feed-forward excitation. The result of this circuit selectivity is a dynamic regulation in the temporal window for integration of excitatory thalamic input, thus revealing a new role for neurogliaform cells in shaping sensory processing.
Publication types
-
Research Support, N.I.H., Intramural
MeSH terms
-
Action Potentials / genetics
-
Animals
-
Excitatory Postsynaptic Potentials / drug effects
-
Excitatory Postsynaptic Potentials / genetics
-
GABA Agents / pharmacology
-
Green Fluorescent Proteins / genetics
-
Humans
-
In Vitro Techniques
-
Inhibitory Postsynaptic Potentials / drug effects
-
Inhibitory Postsynaptic Potentials / genetics
-
Mice
-
Mice, Transgenic
-
Models, Neurological
-
Neural Inhibition / drug effects
-
Neural Inhibition / genetics
-
Neural Inhibition / physiology
-
Neural Pathways / drug effects
-
Neural Pathways / physiology
-
Neuroglia / physiology*
-
Neuropeptide Y / genetics
-
Nipecotic Acids / pharmacology
-
Nonlinear Dynamics*
-
Parvalbumins / metabolism
-
Phosphinic Acids / pharmacology
-
Propanolamines / pharmacology
-
Receptors, Serotonin / genetics
-
Somatosensory Cortex / physiology*
-
Synapses / drug effects
-
Synapses / genetics
-
Synapses / physiology*
-
Thalamus / physiology*
-
Vesicular Glutamate Transport Protein 2 / metabolism
Substances
-
GABA Agents
-
Neuropeptide Y
-
Nipecotic Acids
-
Parvalbumins
-
Phosphinic Acids
-
Propanolamines
-
Receptors, Serotonin
-
Vesicular Glutamate Transport Protein 2
-
serotonin 5 receptor
-
Green Fluorescent Proteins
-
CGP 55845A
-
N-(4,4-diphenyl-3-butenyl)nipecotic acid