Abstract
Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin-expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult Stem Cells / physiology*
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Animals
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Animals, Newborn
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Cell Survival
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Doublecortin Domain Proteins
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Hippocampus / cytology*
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Hippocampus / growth & development
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Interneurons / metabolism*
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Interneurons / ultrastructure
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Luminescent Proteins / genetics
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Membrane Proteins / genetics
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Membrane Proteins / metabolism*
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Mice
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Mice, Inbred C57BL
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Microtubule-Associated Proteins / metabolism
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Nerve Net / metabolism*
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Nerve Tissue Proteins / metabolism
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Neurogenesis / genetics
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Neurogenesis / physiology*
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Neuropeptides / metabolism
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Phenylurea Compounds
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Phosphoproteins / genetics
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Phosphoproteins / metabolism*
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Transduction, Genetic
Substances
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Doublecortin Domain Proteins
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Luminescent Proteins
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Membrane Proteins
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Microtubule-Associated Proteins
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Nerve Tissue Proteins
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Neuropeptides
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Palm protein, mouse
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Phenylurea Compounds
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Phosphoproteins
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ethylene diurea