Characterizing 5-methylcytosine in the mammalian epitranscriptome

Genome Biol. 2013 Nov 29;14(11):215. doi: 10.1186/gb4143.

Abstract

The post-transcriptional modification 5-methylcytosine (m5C) occurs in a wide range of coding and non-coding RNAs. We describe transcriptome-wide approaches to capture the global m5C RNA methylome. We also discuss the potential functions of m5C in RNA and compare them to 6-methyladenosine modifications.

Publication types

  • Review

MeSH terms

  • 5-Methylcytosine / metabolism*
  • Adenosine / analogs & derivatives
  • Adenosine / metabolism
  • Animals
  • Cells, Cultured
  • Epigenesis, Genetic*
  • Humans
  • Mice
  • RNA Processing, Post-Transcriptional*
  • RNA, Untranslated / metabolism
  • Transcriptome*

Substances

  • RNA, Untranslated
  • 5-Methylcytosine
  • N-methyladenosine
  • Adenosine