Abstract
Treatment of mice with the proximate neurotoxin MPTP depletes striatal dopamine levels. Depletion of striatal dopamine and metabolites in MPTP-treated mice is accompanied by depletion of glutathione (GSH) in the substantia nigra (SN). Striatal GSH and nigral amino acid levels were not significantly affected by MPTP. Results suggest that GSH depletion in SN may represent an index of regional vulnerability to metabolic oxidative stress and also of selective susceptibility to the toxic effects of MPTP.
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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3,4-Dihydroxyphenylacetic Acid / metabolism
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Animals
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism
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Dopamine / metabolism
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Extrapyramidal Tracts / drug effects*
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Extrapyramidal Tracts / metabolism
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Glutathione / metabolism*
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Homovanillic Acid / metabolism
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Hydroxyindoleacetic Acid / metabolism
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Male
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Mice
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Pyridines / pharmacology*
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Substantia Nigra / drug effects
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Substantia Nigra / metabolism
Substances
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Pyridines
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3,4-Dihydroxyphenylacetic Acid
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Hydroxyindoleacetic Acid
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Glutathione
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Dopamine
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Homovanillic Acid