Abstract
Rat locus coeruleus neurons recorded under current clamp conditions show anomalous rectification (AR) as indicated by a progressive decrease in slope resistance measured with hyperpolarizing current pulses of increasing amplitude. AR was most prominent at potentials more negative than the K+ equilibrium potential. AR was strongly dependent on external K+ concentration and was blocked by external Ba2+ and Cs+, and intracellular injection of acetate.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Barium / pharmacology
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Cell Membrane Permeability
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Cesium / pharmacology
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In Vitro Techniques
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Ion Channels / drug effects
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Ion Channels / physiology*
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Locus Coeruleus / drug effects
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Locus Coeruleus / physiology*
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Male
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Membrane Potentials
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Potassium / metabolism*
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Rats
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Rats, Inbred Strains
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Sodium / metabolism
Substances
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Ion Channels
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Cesium
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Barium
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Sodium
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Potassium