Abstract
Cocaine was administered to rats for prolonged periods either by repeated injections (10 mg/kg twice daily for 10 days and 12.5 mg/kg 8 times daily for 10 days) or by continuous intravenous infusion (100 mg/kg/day for 21 days). None of the regimens produced long-lasting depletions of dopamine (DA), serotonin (5-HT), or major metabolites in striatum, hippocampus, hypothalamus, or somatosensory cortex. These results suggest that prolonged exposure to cocaine does not produce neurotoxicity like that observed with d-amphetamine or d-methylamphetamine.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3,4-Dihydroxyphenylacetic Acid / metabolism
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Amphetamine / pharmacology
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Animals
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Biogenic Monoamines / metabolism*
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Brain / drug effects*
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Brain / metabolism
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Brain Chemistry / drug effects
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Cocaine / pharmacology*
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Dopamine / metabolism
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Hydroxyindoleacetic Acid / metabolism
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Hypothalamus / drug effects
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Hypothalamus / metabolism
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Limbic System / drug effects
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Limbic System / metabolism
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Male
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Methamphetamine / pharmacology
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Rats
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Rats, Inbred Strains
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Serotonin / metabolism
Substances
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Biogenic Monoamines
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3,4-Dihydroxyphenylacetic Acid
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Serotonin
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Methamphetamine
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Hydroxyindoleacetic Acid
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Amphetamine
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Cocaine
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Dopamine