Axon regeneration in C. elegans

Curr Opin Neurobiol. 2014 Aug:27:199-207. doi: 10.1016/j.conb.2014.04.001. Epub 2014 May 4.

Abstract

Single axon transection by laser surgery has made Caenorhabditis elegans a new model for axon regeneration. Multiple conserved molecular signaling modules have been discovered through powerful genetic screening. In vivo imaging with single cell and axon resolution has revealed unprecedented cellular dynamics in regenerating axons. Information from C. elegans has greatly expanded our knowledge of the molecular and cellular mechanisms of axon regeneration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Axons / physiology*
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism
  • Disease Models, Animal
  • Nerve Regeneration / physiology*
  • Nervous System Diseases* / metabolism
  • Nervous System Diseases* / pathology
  • Nervous System Diseases* / physiopathology
  • Neurons / physiology*

Substances

  • Caenorhabditis elegans Proteins