Quantitative autoradiographic localization of D-1 dopamine receptors in the rat brain: use of the iodinated ligand [125I]SCH 23982

Neurosci Lett. 1986 Aug 4;68(3):261-6. doi: 10.1016/0304-3940(86)90499-4.

Abstract

In vitro autoradiography was used to visualize [125I]SCH 23982 binding sites in rat brain. Labeling was concentrated in the caudate-putamen, accumbens nucleus, olfactory tubercle, substantia nigra pars reticulata and the entopeduncular nucleus. [125I]SCH 23982 labels predominantly D-1 receptors but also labels 5-HT2 receptors in certain areas of the brain. These findings may relate to the distribution of dopamine's cerebral loci of action on D-1 receptors.

MeSH terms

  • Animals
  • Autoradiography
  • Benzazepines* / analogs & derivatives*
  • Benzazepines* / metabolism*
  • Brain / metabolism*
  • Dopamine / metabolism
  • Ligands
  • Microscopy, Fluorescence
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine / metabolism*
  • Receptors, Dopamine D1
  • Receptors, Serotonin / metabolism

Substances

  • 8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol
  • Benzazepines
  • Ligands
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • Receptors, Serotonin
  • Dopamine