Abstract
In vitro autoradiography was used to visualize [125I]SCH 23982 binding sites in rat brain. Labeling was concentrated in the caudate-putamen, accumbens nucleus, olfactory tubercle, substantia nigra pars reticulata and the entopeduncular nucleus. [125I]SCH 23982 labels predominantly D-1 receptors but also labels 5-HT2 receptors in certain areas of the brain. These findings may relate to the distribution of dopamine's cerebral loci of action on D-1 receptors.
MeSH terms
-
Animals
-
Autoradiography
-
Benzazepines* / analogs & derivatives*
-
Benzazepines* / metabolism*
-
Brain / metabolism*
-
Dopamine / metabolism
-
Ligands
-
Microscopy, Fluorescence
-
Rats
-
Rats, Inbred Strains
-
Receptors, Dopamine / metabolism*
-
Receptors, Dopamine D1
-
Receptors, Serotonin / metabolism
Substances
-
8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol
-
Benzazepines
-
Ligands
-
Receptors, Dopamine
-
Receptors, Dopamine D1
-
Receptors, Serotonin
-
Dopamine