Abstract
Rat substantia nigra was injected with 1 microgram of purified pertussis toxin, a substance which inactivates the inhibitory guanine nucleotide regulatory unit of adenylate cyclase. In comparison to saline-injected animals, the pertussis toxin-treated animals showed almost no inhibition of dopaminergic neurons in response to dopamine applied iontophoretically or the dopamine agonist (-)-apomorphine given intravenously. These results provide evidence that a guanine nucleotide regulatory protein is involved as a transducer in mediating the physiological actions of dopamine autoreceptors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Action Potentials / drug effects
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Adenylate Cyclase Toxin*
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Animals
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Apomorphine / pharmacology
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Dopamine / pharmacology
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GTP-Binding Proteins / physiology
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Haloperidol / pharmacology
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Male
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Neural Inhibition / drug effects*
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Pertussis Toxin*
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Rats
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Receptors, Dopamine / drug effects*
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Receptors, Dopamine / physiology
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Receptors, Dopamine D2
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Substantia Nigra / drug effects*
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Substantia Nigra / physiology
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Virulence Factors, Bordetella / pharmacology*
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gamma-Aminobutyric Acid / pharmacology
Substances
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Adenylate Cyclase Toxin
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Receptors, Dopamine
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Receptors, Dopamine D2
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Virulence Factors, Bordetella
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gamma-Aminobutyric Acid
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Pertussis Toxin
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GTP-Binding Proteins
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Haloperidol
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Apomorphine
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Dopamine